The profiler can be access by pressing F8 on your keyboard. It offers some very helpful filtering features making it easy to expand or retract your results. The tools we generally use to do this are GPU Nesting and Duration. GPU Nesting filters based on how many levels deep in the call graph you want to see while the Duration Filter is the minimum duration that an entry needs to have to show up in the list. If the process does not meet these criteria they are filtered out. This can be very useful as typically we wont care about micro costs when investigating a performance problem.
The profiler is a powerful tool and can give you realtime, organized information regarding your project. It also does an excellent job of denoting where the performance cost is being felt.